genomic stabilities การใช้

• Microbes affect genomic stability, resistance to cell death and proliferative signaling.
• In addition to providing genomic stability, caretakers also provide chromosomal stability.
• Mutations in the human homologues of the Mut proteins affect genomic stability, which can result in microsatellite instability ( MI ).
• Finally, he elucidated unexpected links between these mRNA processing reactions and transcription, DNA damage signaling and maintenance of genomic stability.
• FOXM1 is known to play a key role in cell cycle progression where endogenous FOXM1 expression peaks at chromosomal segregation and genomic stability.
• In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation.
• HDR maintains genomic stability by repairing broken DNA strands; it is assumed to be error free because of the use of a template.
• Global hypomethylation results in decreased genomic stability, while local hypermethylation of tumour suppressor gene prognostic value, and can help to guide the best course of treatment.
• Many proteins involved in genomic stability maintenance rely on the PML-NBs for targeting, and PML loss thus leads to a decrease in repair efficiency within the cell.
• This genomic stability confers an advantage to targeting endothelial cells using antiangiogenic therapy, compared to chemotherapy directed at cancer cells, which rapidly mutate and acquire'drug resistance'to treatment.
• The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell cycle checkpoint activation, recombinational repair and maintenance of genomic stability.
• The emerging picture clearly is that RecQ helicases in concert with Top 3 are involved in maintaining genomic stability and integrity by controlling recombination events, and repairing DNA damage in the G2-phase of the cell cycle.
• ASF / SF2 is involved in genomic stability; it is thought that RNA Polymerase recruits ASF / SF2 to nascent RNA transcripts to impede formation of mutagenic DNA : RNA hybrid R loop structures between the transcript and the template DNA . In this way, ASF / SF2 is protecting cells from the potential deleterious effects of transcription itself.